High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates
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چکیده
منابع مشابه
High mutation rate of a long microsatellite allele in Drosophila melanogaster provides evidence for allele-specific mutation rates.
Within recent years, microsatellite have become one of the most powerful genetic markers in biology. For several mammalian species, microsatellite mutation rates have been estimated on the order of 10(-3)-10(-5). A recent study, however, demonstrated mutation rates in Drosophila melanogaster of at least one order of magnitude lower than those in mammals. To further test this result, we examined...
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Microsatellite loci play an important role as markers for identi cation, disease gene mapping and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which however are subject to ascertainment bias. This bias arises for example when a locus is selected based on its large allele size in one species (cognate species 1), in which ...
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We summarize available data on the frequencies of alleles at microsatellite loci in human populations and compare observed distributions of allele frequencies to those generated by a simulation of the stepwise mutation model. We show that observed frequency distributions at 108 loci are consistent with the results of the model under the assumption that mutations cause an increase or decrease in...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1998
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a025855